BFD-10 Freeze Dryer


Vikumer’s BFD-10 freeze dryer is designed for pilot production and laboratory applications include freeze drying recipe research and development, process optimization, clinical trials, small scale production and preparation of technology transfer.

A variety of tailored options are available to meet your specific needs. And the machine structure can be customized to fit your laboratory and clean room.

Design Highlights

The BFD-10 freeze dryer has the similar technical features and system performance as the commercial larger units such as the PLC based controller, temperature controlled shelves, pressure control, FDA and cGLP compliant. Which enable it fits a wide array of freeze drying applications from laboratory investigation to small diagnostics production. Versatile to handle recipes development, processes optimization and clinical trials, as an intermediate for cycle transfer to manufacturing scale.

BFD-10 Pilot Freeze Dryer
BFD-10S Pilot Freeze Dryer
BFD-10 Pilot Freeze Dryer System

2-Chamber System

Drying chamber and ice condenser are separate, connected by a spool piece and an isolation valve can be installed between to perform pressure rise test. The drying chamber is rectangular shape that offers maximum space using rate, and the ice condenser is cylindrical shape for easy defrost and water drain.

High Efficiency Shelves Heating and Cooling

Shelves in BFD-10 system are always temperature controlled: heat transfer fluid circulates inside sandwich type heat-plates for product pre-freeze and later heating for sublimation. The shelves are cooled through a brazed plate heat exchanger and heated by an electric bar. PID control and heating/cooling rate >1C/Min which is same as the production freeze dryers, ideal for R&D activities.

Precise Temperature Control

The heat transfer fluid based shelf system guarantees uniform temperature of all heat-plates, an additional heat-plate is installed on top of shelf module to provide extra energy for thermal balance. Temperature sensors have been installed in both the fluid inlet and return pipe, as well as the fluid heating bar point, to control and monitor shelves temperature. Temperature variance between heat-plates and plate points are less than +/-1C.

Advanced Control System

Vekuma’s BFD-10 laboratory freeze dryer provides control versatility with the most advanced PLC system and LYO-PILOT interface, which allows control of the freeze dryer functions via a user-friendly touch screen HMI and has the functions of:

  • Alive display main components working status and key parameters.
  • Freeze drying recipes management.
  • Real-time freeze drying trend.
  • Data logging and can be exported via USB.
  • Automatic and semi-automatic working.
  • Alarms information.
  • Users, authorization and password.
  • Probes and gauge calibration.

Technical Parameters

Model BFD-10 Standard BFD-10S Stoppering
Shef Area 0.47~0.94m2 0.47~0.94m2
Shelves No. (3~6)+1 (3~6)+1
Shelves Size 350*450mm 350*450mm
Shelves Temp. -55C~+70C -55C~+70C
Condenser 15Kgs/24Hrs 15Kgs/24Hrs
Condenser Temp. -85C -85C
Final Vacuum 0.01mBar 0.01mBar
Power Install 7.5Kw 8Kw
Voltage 380V/50Hz/3P 380V/50Hz/3P
Size W/1350*D/950*H/1850mm W/1450*D/1200*H/1950mm
Weight 750Kgs 800Kgs
Vials 2R/4R / 3528
Vials 6R/8R / 1800
Vials 10R/15R / 1512

Standard Features

  • All-in-one structure. Plug and play deliver.
  • Powder coated exterior with casters and height adjustable feet.
  • All sides panels can be opened for maintenance.
  • Stainless steel, rectangular drying chamber, inner wall Ra<0.6um.
  • Transparent drying chamber door, lubricate free door gasket.
  • Sandwich type shelves, silicone oil based system, shelves temperature controllable from -55C to +70C.
  • Individual ice condenser, vapor collect capacity 15kgs in 24hrs, 30kgs max.
  • Condenser final temperature -85C.
  • Condenser auto defrosting.
  • 2-stage oil sealed rotary vane vacuum pump.
  • Vacuum adjustable.
  • Cascade compressor system, air cooling method.
  • PLC and user-friendly touch screen based control system:
    • Alive display main components working status.
    • Freeze drying recipes management.
    • Real-time freeze drying curve.
    • Drying data download via USB.
    • Automatic and semi-automatic working.
    • Alarms information.
    • Users, authorization and password protection.
    • Probes and gauge calibration.
  • Side mounted vacuum break valve.
  • Side mounted water drain valve.
  • Meet cGMP, cGLP and FDA.
  • Qualification and validation documents.

System Performance

  • Chamber inner wall roughness Ra<0.6um
  • Shelves flatness <0.5mm/m
  • Shelves roughness Ra<0.4um
  • Shelf cooling: +20C ~ -40C <60min
  • Shelf lowest: -55C (+/-2C)
  • Shelf heating: -40C ~ +20C <60min
  • Shelf highest: +70C (+/-1.5C)
  • Condenser inner wall roughness Ra<0.6um
  • Condenser coils roughness Ra<0.4um
  • Condenser cooling: RT ~ -40C <30min
  • Condenser final: -85C
  • Defrosting: <60Min
  • Vacuum final: <1Pa

Options and Accessories

  • Clean room configuration.
  • Stoppering system for vials closing under vacuum.
  • Condenser & chamber isolation valve.
  • Vacuum control system.
  • Capacitive vacuum gauge.
  • PC control and software.
  • Eutectic point detector.
  • Lateral manifold rack for flasks.
  • S/S316L material.
  • -65C shelves.
  • -110C condenser.
  • Product trays: standard trays, bottom removable trays or coated trays.
  • Scroll vacuum pump.
  • Water cooled compressor.
  • Reciprocating compressor.
  • H2O2 sterilization package.


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